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Behavior in the open field was not consistently affected by any

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drug type. When administered for 14 and/or 28 days (but not for 1 day), imipramine, desipramine, Venlafaxine

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( Effexor ), phenelzine, and Bupropion ( Wellbutrin SR ) significantly increased struggling behavior of SwLo advil pain relief that the high concentration of DA in the whole brain could be a limiting factor for the antidepressant-like effect of antidepressants such as tranylcypromine

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and seems to play a minor role in the antidepressant-like activity of another antidepressant such as Bupropion ( Wellbutrin SR ) in the FST.. A trend for an inversely proportional linear relationship [(magnitude

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of the antidepressant-like effect) -0.0145 x (concentration of DA in the whole brain) 34.773 (r 0.276)] was observed between the magnitude of the antidepressant-like effect and the concentrations of DA in the

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whole brain, but this correlation was not significant. Long-term administration of phenelzine and Bupropion ( Wellbutrin SR ) also significantly decreased floating behavior in the swim test, although amphetamine also had this effect at all times of administration. To assess specificity of response, the nonantidepressant drugs amphetamine, caffeine, and haloperidol were also tested. Effects of antidepressant drugs on rats bred for low activity in the swim test.To determine responsivity

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to antidepressant medication of Sprague-Dawley rats bred for low activity in the swim test [Swim Low-Active (SwLo) rats], these animals were given different antidepressant drugs via subcutaneously implanted minipumps for 1, 12, or 26 days, and then were tested for activity in the swim test and 2 days later in the open field. No nonantidepressant drug significantly elevated struggling activity. It is concluded that,

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based on pharmacological response profile in the swim test, SwLo rats represent depression that is responsive to potent norepinephrine reuptake-blocking antidepressants and also MAOIs; atypical depression may fit this profile. Is dopamine

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a limiting factor of the antidepressant-like effect in the mouse forced swimming test?To study the role of dopamine (DA) in antidepressant-like effect in the forced swimming test (FST), the relationship between the magnitude of the antidepressant-like effect of drugs [Citalopram ( Celexa ), Fluoxetine ( Prozac ), Paroxetine ( Paxil ) (selective serotonin reuptake inhibitors), desipramine (tricyclic antidepressant), maprotiline (tetracyclic antidepressant), Bupropion ( Wellbutrin SR ) (DA reuptake inhibitor), and tranylcypromine (inhibitor of monoamine oxidase)] and the corresponding concentration of DA in the whole brain of mice was investigated. For comparison, several drugs were also tested in rats bred for high activity in the swim test [Swim High-Active (SwHi) rats]. No significant effects of antidepressants were seen in SwHi rats. Amitriptyline ( Elavil ) and Fluoxetine ( Prozac ) were ineffective in altering either struggling or floating in SwLo rats; however, a high dose of an SSRI (sertraline) did reduce floating, but this type of effect is probably not indicative of antidepressant action.